Search results for " capture" in Articles / App Notes
Article
Gene Therapies Push Viral Vector Production
Other innovations, such as affinity ligands for specific AAV serotypes are being developed for use with these technologies to further enhance the resolution of the capture step. A major challenge rema…
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
Given these reasons, it isn’t surprising to see why barriers to knowledge sharing and collaboration have been so hard to overcome, and how differences in terminology and the way data is captured can p…
Article
Nurturing Knowledge from Disparate Data Streams
The volume and complexity of these data make the move to electronic capture inescapable, he adds.
For many of these techniques, however, the inevitable evolution from paper-based data collectio…
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
MabSelect™ PrismA protein A resin was selected for the capture step. Most fragments could be removed as early as the capture step using gradient elution from pH 5 to 3.5, without the need for addition…
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The Challenge of Disruptive Technologies in Bioprocessing
An example of the latter may be the use of affinity chromatography in the capture step of antibody processes, Jagschies says.
“When we look at the biologics market dynamics for treatment of dis…
Article
Challenges in Cell Harvesting Prompt Enhancements
The upper layer captures coarse particles, and the bottom layer captures smaller particles, thus reducing premature plugging and increasing the filtration capacity (3).
Through the use of a nu…
Article
Making the Move to Continuous Chromatography
For Sulzberger, continuous chromatography should be of interest for all processes that start with a capture step and where there is a desire for straight through processing. “The premise behind contin…
Article
Best Practices for Data Integrity
It enables you to find correlations that otherwise would have been impossible or not cost effective to capture with a paper-based system.
Ideally, what you are after is a system that me…
Article
Being Thorough When Transferring Technology
Procedures that govern technical documentation requirements gated to each stage of development ensure that critical information is captured and available for tech transfer. For example, required clini…
Article
Continuous Processing for the Production of Biopharmaceuticals
Researchers have recently demonstrated the first integration of high-density perfusion cell culture with a capture step through a four-column periodic counter-current chromatography (PCC) (1). The hig…